BDBM50439629 CHEMBL2419595::US8993586, 102

SMILES COc1cc2cc(ccc2cn1)C(=O)N1CCC2(CC1)Cc1cn(nc1C(=O)N2)C(C)(C)C

InChI Key InChIKey=CKSGXKWTIWDGQU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50439629   

TargetAcetyl-CoA carboxylase 1(Human)
Pfizer

US Patent
LigandPNGBDBM50439629(CHEMBL2419595 | US8993586, 102)
Affinity DataIC50: 78nMpH: 7.5Assay Description:Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
Go to US Patent

TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

US Patent
LigandPNGBDBM50439629(CHEMBL2419595 | US8993586, 102)
Affinity DataIC50: 12nMAssay Description:Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
Go to US Patent

TargetAcetyl-CoA carboxylase 1(Human)
Pfizer

US Patent
LigandPNGBDBM50439629(CHEMBL2419595 | US8993586, 102)
Affinity DataIC50: 74nMAssay Description:Inhibition of human ACC1 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

US Patent
LigandPNGBDBM50439629(CHEMBL2419595 | US8993586, 102)
Affinity DataIC50: 29nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed