BDBM50440530 CHEMBL2426167::US20240270735, Compound A103

SMILES Cc1cc(NC(=O)Nc2nnc(s2)-c2ccncc2)ccc1F

InChI Key InChIKey=RQLLFUCCUVJQRT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50440530   

TargetRecQ-like DNA helicase BLM(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50440530(CHEMBL2426167 | US20240270735, Compound A103)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of BLM (unknown origin) by gel-based DNA unwinding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM50440530(CHEMBL2426167 | US20240270735, Compound A103)
Affinity DataIC50: 4nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 8(Human)
Chan Zuckerberg Biohub

US Patent
LigandPNGBDBM50440530(CHEMBL2426167 | US20240270735, Compound A103)
Affinity DataIC50: 65nMAssay Description:The CDK19/CDK8 IC50 values were measured to evaluate activity and to determine CDK19/CDK8 selectivity. The IC50 values of the disclosed compounds was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent