BDBM50442702 CHEMBL2442511::US9296728, 26

SMILES OC(=O)c1cc2ccc(cc2oc1=O)N1CCCC1

InChI Key InChIKey=AZGXIHFVKOMJRL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50442702   

TargetMonocarboxylate transporter 1(Rat)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50442702(CHEMBL2442511 | US9296728, 26)
Affinity DataIC50: 220nMpH: 7.43 T: 2°CAssay Description:The entire lactate uptake studies for the inhibition of MCT1 were carried out on RBE4 (Rat Brain Endothelial 4) cells. The expression of MCT1 on thes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2017
Entry Details
Go to US Patent

TargetMonocarboxylate transporter 1(Rat)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50442702(CHEMBL2442511 | US9296728, 26)
Affinity DataIC50: 380nMAssay Description:Inhibition of MCT1 in rat brain endothelial 4 cells assessed as L-[14C]-Lactate Uptake after 15 mins by scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetMonocarboxylate transporter 4(Human)
Institut De Recherche Exp£Rimentale Et Clinique (Irec)

Curated by ChEMBL
LigandPNGBDBM50442702(CHEMBL2442511 | US9296728, 26)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in cult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed