BDBM50442901 Abietic Acid::acs.jmedchem.1c00409_ST.770

SMILES CC(C)C1=CC2=CC[C@@H]3[C@@]([C@H]2CC1)(CCC[C@@]3(C)C(=O)O)C

InChI Key InChIKey=RSWGJHLUYNHPMX-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50442901   

LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataIC50: 5.25E+3nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataIC50: 2.69E+3nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataIC50: 2.00E+4nMAssay Description:In vitro inhibitory activity against pyruvate dehydrogenase kinase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2018
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataIC50: 1.89E+5nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataKi:  1.47E+3nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50442901(Abietic Acid | acs.jmedchem.1c00409_ST.770)
Affinity DataKi:  4.08E+3nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed