BDBM50443365 CHEMBL3086078

SMILES CN(C)C(=O)Oc1cc2oc(=O)c(Cc3cccc(NS(N)(=O)=O)c3F)c(C)c2cc1F

InChI Key InChIKey=WBARVJREQICCOV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50443365   

TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 30 mins followed by NADPH and substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 30 mins post NADPH addition followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 30 mins followed by NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443365(CHEMBL3086078)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 30 mins post NADPH addition measured after 5 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed