BDBM50443366 CHEMBL3086065

SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1

InChI Key InChIKey=NRWASCVTZULAQF-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50443366   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 7nMAssay Description:Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 8nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ALK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FAK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of BRK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK-1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK-2 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MET (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DDR1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of InsR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AXL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RON (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed