BDBM50443501 CHEMBL3085798

SMILES Cc1cc(NC(=O)c2ccc(Oc3c(Cl)cnc4nc([nH]c34)-c3cn(C)nc3C)cc2)on1

InChI Key InChIKey=AFWWHBTVEBALQB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443501   

TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443501(CHEMBL3085798)
Affinity DataIC50: 71nMAssay Description:Inhibition of N-terminal HIS-tagged aurora-A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443501(CHEMBL3085798)
Affinity DataIC50: 95nMAssay Description:Inhibition of autophosphorylation of N-terminal Myc tagged aurora-A at T288 in human HCT116 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443501(CHEMBL3085798)
Affinity DataIC50: 693nMAssay Description:Inhibition of full-length aurora-B (unknown origin) using 5FAMLRRASLG-CONH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50443501(CHEMBL3085798)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of N-terminal Myc tagged aurora-B-mediated histone H3 phosphorylation at S10 in human HCT116 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed