BDBM50443627 CHEMBL3092450::US9216998, 5

SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F

InChI Key InChIKey=MXODNNNPSJJTNP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443627   

TargetEndothelial lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50: 14nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND 384-well plates (Corning, Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
Go to US Patent

TargetEndothelial lipase(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50: 17nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND 384-well plates (Corning, Lo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
Go to US Patent

TargetEndothelial lipase(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443627(CHEMBL3092450 | US9216998, 5)
Affinity DataIC50: 14nMAssay Description:Inhibition of human endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed