BDBM50445336 CHEMBL1797639

SMILES NC1CC1c1cccc(OCC[C@H](NC(=O)c2ccccc2)C(=O)NCc2ccccc2)c1

InChI Key InChIKey=DTPSXFMGMQOVTG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50445336   

TargetLysine-specific histone demethylase 1A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acid residues) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human MAO-B using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.30E+5nMAssay Description:Inhibition of human MAO-A using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 2(Human)
Waseda University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of recombinant human LSD2 using H3K4 peptide as substrate assessed as decrease in H3K4 demethylation after 1 hr by mass spectroscopic anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human LSD1 using H3K4 peptide as substrate by peroxidase-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acids) expressed in Escherichia coli BL21 (DE3) cells using H3K4me2 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.30E+5nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed