BDBM50446448 CHEMBL3109944

SMILES Cn1cc(cn1)-c1cc2cnc(Nc3ccc(cc3Cl)-c3cnco3)cc2n1C(=O)OC(C)(C)C

InChI Key InChIKey=OYORONOSHXMKGA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50446448   

TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446448(CHEMBL3109944)
Affinity DataIC50: 260nMAssay Description:Inhibition of Myc-tagged wild type MPS1 autophosphorylation in human HCT116 cells after 2 hrs in presence of proteosome inhibitor MG132More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446448(CHEMBL3109944)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of full length CDK2/Cyclin A (unknown origin) using 5FAMQSPKKG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446448(CHEMBL3109944)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal 6XHis-tagged/GST-tagged full length human MPS1 expressed in recombinant baculovirus infected sf9 insect cells using 5FAM-DHT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446448(CHEMBL3109944)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His-tagged Aurora A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed