BDBM50446462 CHEMBL3109956

SMILES COc1ccc(Nc2cc3[nH]c(cc3cn2)-c2cn[nH]c2)c(Cl)c1

InChI Key InChIKey=YJIODQXQURPDDG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50446462   

TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446462(CHEMBL3109956)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal 6XHis-tagged/GST-tagged full length human MPS1 expressed in recombinant baculovirus infected sf9 insect cells using 5FAM-DHT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446462(CHEMBL3109956)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of N-terminal His-tagged Aurora A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446462(CHEMBL3109956)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of full length CDK2/Cyclin A (unknown origin) using 5FAMQSPKKG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446462(CHEMBL3109956)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length Aurora B (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed