BDBM50446481 CHEMBL3110004::US10011611, TMP269::US10722597, Compound TMP-269

SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1

InChI Key InChIKey=HORXBWNTEDOVKN-UHFFFAOYSA-N

Data  16 KI  64 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 80 hits for monomerid = 50446481   

TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 753nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC4 (627 to 1084 residues) expressed in Sf9 insect cells using Boc-Lys(Tfa)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 8.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 97nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 157nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 157nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 4.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 318nMAssay Description:Inhibition of HDAC4 (unknown origin) using trypsin and Ac-peptide as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 210nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 890nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 180nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 67nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 8.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 4.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 40.9nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2017
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 191nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 5.21E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 432nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 990nMAssay Description:Inhibition of C-terminal His-tagged human HDAC5 (656-1122 residues) expressed in baculovirus expression system using Ac-peptide substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 49nMAssay Description:Inhibition of HDAC9 (unknown origin) using fluorogenic HDAC class 2a as substrate measured after 1 to 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 112nMAssay Description:Inhibition of recombinant human HDAC7 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 263nMAssay Description:Inhibition of recombinant human HDAC5 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 127nMAssay Description:Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 9 [604-1066](Human)
Reaction Biology

US Patent
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 12.9nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 7 [518-592](Human)
Reaction Biology

US Patent
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 32.4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Children'S Hospital Affiliated To Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 19.4nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 65.7nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 4 [627-1085](Human)
Reaction Biology

US Patent
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 213nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

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