BDBM50447619 CHEMBL3112719

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1cnc2nc(N)nc(-c3ccncc3)c2c1

InChI Key InChIKey=HOMZOHHXRBSSCZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447619   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447619(CHEMBL3112719)
Affinity DataIC50: 36nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate after 1 hr by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447619(CHEMBL3112719)
Affinity DataIC50: 18nMAssay Description:Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447619(CHEMBL3112719)
Affinity DataIC50: 18nMAssay Description:Inhibition of mTOR (unknown origin) after 40 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50447619(CHEMBL3112719)
Affinity DataIC50: 36nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincubated for 15 mins by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed