BDBM50447776 CHEMBL3113538::US9242970, 212

SMILES CCOc1cccc(OC)c1C1CCCC(=O)N1Cc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=IXHUYDMFYJGNQN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447776   

TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447776(CHEMBL3113538 | US9242970, 212)
Affinity DataIC50: 37nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447776(CHEMBL3113538 | US9242970, 212)
Affinity DataIC50: 216nMT: 2°CAssay Description:In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447776(CHEMBL3113538 | US9242970, 212)
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human orexin 1 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM50447776(CHEMBL3113538 | US9242970, 212)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human orexin 2 receptor expressed in CHO cells assessed as inhibition of orexin-A-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed