BDBM50450880 CHEMBL4204566

SMILES CC(C)n1cnc2c(Nc3cnn(C)c3)nc(nc12)N1C[C@H](F)[C@H](C1)NC(=O)C=C

InChI Key InChIKey=IRMHXRHXLFRZFM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450880   

TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50450880BDBM50450880(CHEMBL4204566)
Affinity DataKi:  152nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50450880BDBM50450880(CHEMBL4204566)
Affinity DataIC50: 713nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50450880BDBM50450880(CHEMBL4204566)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed