BDBM50451222 CHEMBL4210391

SMILES COc1cccc2n(c(nc12)C(F)F)-c1nc(N2CCOCC2)c2nnn(C3CCN(CC3)S(C)(=O)=O)c2n1

InChI Key InChIKey=KNVOFWNBZNIMKY-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50451222   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Auckland

Curated by ChEMBL

LigandBDBM50451222(CHEMBL4210391)Copy SMILESCopy InChI

Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminal His-tagged human PI3K p110alpha/p85alpha expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/15/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of Auckland

Curated by ChEMBL

LigandBDBM50451222(CHEMBL4210391)Copy SMILESCopy InChI

Affinity DataIC50: 262nMAssay Description:Inhibition of N-terminal His-tagged human PI3K p110beta/p85alpha expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/15/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Auckland

Curated by ChEMBL

LigandBDBM50451222(CHEMBL4210391)Copy SMILESCopy InChI

Affinity DataIC50: 152nMAssay Description:Inhibition of N-terminal His-tagged human PI3K p110delta/p85alpha expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/15/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL