BDBM50451275 CHEMBL4205716

SMILES OC(=O)c1ccc(NC(=O)c2ccc(NC(=O)c3ccco3)cc2)cc1O

InChI Key InChIKey=HUPASKFDURPNGE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50451275   

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50451275(CHEMBL4205716)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant SIRT6 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50451275(CHEMBL4205716)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50451275(CHEMBL4205716)
Affinity DataIC50: 4.82E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50451275(CHEMBL4205716)
Affinity DataIC50: 5.99E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as reduction in NAD+-dependent deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed