BDBM50451426 CHEMBL4208064

SMILES CS(=O)(=O)N1CCN(Cc2cn3nc(nc(N4CCOCC4)c3n2)-c2cnc(N)nc2)CC1

InChI Key InChIKey=MZDVYDDLVZYLGV-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50451426   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by Tracer Red dye based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataKi:  1.5nMAssay Description:Inhibition of full-length human P110alpha (1 to 1068 residues)/N-terminal GST-fused p85alpha (1 to 724 residues) expressed in baculovirus expression ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human full-length p85alpha expressed in baculovirus infected Sf21 insect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataKi:  41nMAssay Description:Inhibition of recombinant full-length human N-terminal His6-tagged p110gamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataKi:  388nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50451426(CHEMBL4208064)
Affinity DataKi:  1.84E+3nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system by AlexaFluor647-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed