BDBM50451564 CHEMBL4203948

SMILES CCN[C@@H]1CCC=C([C@H]1COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1)c1ccc(F)cc1

InChI Key InChIKey=VQMLBMJANZMDDR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50451564   

TargetSodium channel protein type 9 subunit alpha(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 59nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 59nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human ERG by Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 2.52E+4nMAssay Description:Inhibition of human Nav1.4 at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 4.34E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451564(CHEMBL4203948)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed