BDBM50451860 CHEMBL4215481

SMILES Fc1ccc2CC[C@@](N(C(=O)[C@@H]3CCC(=O)N3c3cc(ccn3)C#N)c3cccc(F)c3)(C(=O)NC3CC(F)(F)C3)c2c1

InChI Key InChIKey=YXBCPMUWOSWJBM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50451860   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shanghai Haihe

Curated by ChEMBL
LigandPNGBDBM50451860(CHEMBL4215481)
Affinity DataIC50: 138nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate after 60 mins by resazurin dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed