BDBM50452215 CHEMBL4212115::US10647727, Example 2

SMILES C[C@H](c1ccc(cc1)C(F)(F)F)Nc2c3cnn(c3nc(n2)Cl)C

InChI Key InChIKey=ZYAUUUUKFRDVKN-UHFFFAOYSA-N

Data  3 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50452215   

LigandPNGBDBM50452215(CHEMBL4212115 | US10647727, Example 2)
Affinity DataKi:  237nMAssay Description:Binding affinity to PDE2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452215(CHEMBL4212115 | US10647727, Example 2)
Affinity DataKi:  237nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50452215(CHEMBL4212115 | US10647727, Example 2)
Affinity DataKi:  392nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)