BDBM50452840 CHEMBL4209940

SMILES COc1ccc2[C@@H](N(CCc2c1)C(=O)\C=C\C(O)=O)C(=O)Nc1cc(F)c(c(F)c1)[Si](C)(C)C

InChI Key InChIKey=HZWNTEIKOIMAGC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452840   

TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452840(CHEMBL4209940)
Affinity DataIC50: 4.10nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452840(CHEMBL4209940)
Affinity DataIC50: 38nMAssay Description:Inverse agonist activity at RORgammat in human Jurkat cells assessed as inhibition of transcriptional activity after overnight incubation by human IL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed