BDBM50452843 CHEMBL4217478

SMILES COc1ccc2[C@@H](N(CCc2c1)C(=O)CC(C)CC(O)=O)C(=O)Nc1cc(F)c(c(F)c1)[Si](C)(C)C

InChI Key InChIKey=MRAIKFCRUOWHBD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452843   

TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452843(CHEMBL4217478)
Affinity DataIC50: 3.80nMAssay Description:Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452843(CHEMBL4217478)
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at RORgammat in human Jurkat cells assessed as inhibition of transcriptional activity after overnight incubation by human IL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed