BDBM50453946 CHEMBL4205336

SMILES [H][C@]12CC[C@](O)(CC1)[C@H](N2C(=O)[C@@H](NC(=O)c1ccc2ccccc2c1)C(C)C)C(=O)N[C@H]1CC(=O)OC1O

InChI Key InChIKey=RTSYLXJCADNYDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50453946   

TargetCaspase-1(Human)
Edelris

Curated by ChEMBL
LigandPNGBDBM50453946(CHEMBL4205336)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant caspase1 expressed in Escherichia coli using AC-WEHD-AMC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Edelris

Curated by ChEMBL
LigandPNGBDBM50453946(CHEMBL4205336)
Affinity DataIC50: 86nMAssay Description:Inhibition of caspase1 in human THP1 cells assessed as LPS/ATP-induced IL-1beta release preincubated for 24 hrs in presence of LPS measured after ove...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed