BDBM50455463 CHEMBL215205

SMILES Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1

InChI Key InChIKey=AYZRKFOEZQBUEA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50455463   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of recombinant human CDK2/cyclin A using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate after 15 mins by fluorescence assay relative to cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human CDK9/cyclin T1 using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate after 90 mins by fluorescence assay relative to con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Palack�

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin) expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 350nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 350nMAssay Description:Inhibition of human full-length N-terminal GST/His6-tagged CDK9 (1 to 372 residues)/His6-tagged Cyclin-T1 (1 to 726 residues) expressed in sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50455463(CHEMBL215205)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using GST-CTD and gamma-32P-ATP as substrate incubated for 5 min by Differential scanning fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed