BDBM50457316 CHEMBL4215275::US10662187, Compound 89::US10793566, Compound 6

SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3c(OC)cncc23)c1F

InChI Key InChIKey=LLRUOFRCNQYKAO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50457316   

TargetTyrosine-protein kinase BTK(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 100nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 550nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 5.50E+3nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 5.50E+3nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM50457316(CHEMBL4215275 | US10662187, Compound 89 | US107935...)
Affinity DataIC50: 550nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent