BDBM50457447 CHEMBL4203441

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#C)cc1Nc1ccc2ncn(C)c(=O)c2c1

InChI Key InChIKey=WROPEIVESXJWPS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457447   

TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50457447(CHEMBL4203441)
Affinity DataIC50: 15nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50457447(CHEMBL4203441)
Affinity DataIC50: 34nMAssay Description:Inhibition of human His-tagged BRAF V600E mutant (513 to 693 residues) using inactive MEK as substrate after 30 mins by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed