BDBM50457453 CHEMBL4212142

SMILES CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)NC1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1

InChI Key InChIKey=GXEGTVQATHKFDH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50457453   

TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50457453(CHEMBL4212142)
Affinity DataIC50: 157nMAssay Description:Inhibition of BRAF V600E mutant in human SK-MEL-239 cells assessed as reduction in ERK phosphorylation after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed