BDBM50457751 CHEMBL4217087

SMILES COc1cc2c(cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1)N(C)C1CCN(C)CC1

InChI Key InChIKey=JHXDJXMQZRAMSL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457751   

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50457751(CHEMBL4217087)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50457751(CHEMBL4217087)
Affinity DataIC50: 935nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50457751(CHEMBL4217087)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL
LigandPNGBDBM50457751(CHEMBL4217087)
Affinity DataIC50: 8nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed