BDBM50457823 CHEMBL4204070

SMILES Cn1cnc(c1)-c1cnc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O

InChI Key InChIKey=XBJKLAZNUXEFFR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457823   

TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50457823(CHEMBL4204070)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50457823(CHEMBL4204070)Copy SMILESCopy InChI

Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL