BDBM50457836 CHEMBL4213038

SMILES Cn1cnc(c1)-c1cnc(N)c(O[C@@H]2CN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1

InChI Key InChIKey=BCBOSJKHVGJHKV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457836   

TargetHigh affinity nerve growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50457836(CHEMBL4213038)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50457836(CHEMBL4213038)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL