BDBM50458059 CHEMBL4209801

SMILES CN1CCN(CC1)c1ccc(Nc2cc3c(nc(Nc4ccccc4)nc3cn2)N2CCCC2)nc1

InChI Key InChIKey=GYUBFPFWHQQLPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50458059   

TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50458059(CHEMBL4209801)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of wild type EGFR L858R mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50458059(CHEMBL4209801)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50458059(CHEMBL4209801)
Affinity DataIC50: 85nMAssay Description:Inhibition of wild type EGFR L858R/T790M double mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed