BDBM50458227 CHEMBL4205653

SMILES Brc1ccc(COc2ccc3C(=O)\C(Cc3c2)=C\c2ccc(OCCCN3CCCCC3)cc2)cc1

InChI Key InChIKey=JJPGVZOMHHYPJU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50458227   

TargetHistamine H3 receptor(Human)
Heinrich Heine University Duesseldorf

Curated by ChEMBL
LigandPNGBDBM50458227(CHEMBL4205653)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Heinrich Heine University Duesseldorf

Curated by ChEMBL
LigandPNGBDBM50458227(CHEMBL4205653)
Affinity DataIC50: 262nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Heinrich Heine University Duesseldorf

Curated by ChEMBL
LigandPNGBDBM50458227(CHEMBL4205653)
Affinity DataIC50: 276nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate after 15 to 20 mins by discontinuous ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Heinrich Heine University Duesseldorf

Curated by ChEMBL
LigandPNGBDBM50458227(CHEMBL4205653)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected insect cell membranes using kynuramine as substrate after 15 to 20 mins by discontinuous ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed