BDBM50458489 CHEMBL4217364

SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(CC2CC(C2)C(=O)NO)ccc1OCC

InChI Key InChIKey=GTSZATFSVLYIRU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50458489   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PDE3A (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full-length human PDE9A2 expressed in baculovirus infected Sf9 insect cells using cGMP as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal GST-tagged full-length recombinant human PDE5A1 (1 to 875 residues) expressed in Sf9 insect cells using cGMP as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 310nMAssay Description:Inhibition of C-terminal 6xHis/FLAG-tagged full-length recombinant human HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using fluorogenic su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 81nMAssay Description:Inhibition of full-length recombinant human HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using fluorogenic substrate incubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50458489(CHEMBL4217364)
Affinity DataIC50: 309nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed