BDBM50458739 CHEMBL4215969

SMILES CS(=O)(=O)C1(CC1)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)cc1C(F)(F)F

InChI Key InChIKey=QOFAEMKKSYNAQU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50458739   

LigandPNGBDBM50458739(CHEMBL4215969)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human full length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458739(CHEMBL4215969)
Affinity DataIC50: 314nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/recombinant human full length p85alpha expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shanghai Haiyan Pharmaceutical Technology

Curated by ChEMBL
LigandPNGBDBM50458739(CHEMBL4215969)
Affinity DataIC50: 288nMAssay Description:Inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458739(CHEMBL4215969)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/recombinant human full length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shanghai Haiyan Pharmaceutical Technology

Curated by ChEMBL
LigandPNGBDBM50458739(CHEMBL4215969)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4EBP1 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed