BDBM50458749 CHEMBL4211915
SMILES C[C@H]1COCCN1c1nc(cc(n1)C1(CC1)S(C)(=O)=O)-c1cnc(N)cc1F
InChI Key InChIKey=LBIPJQHFIZPQHA-UHFFFAOYSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50458749
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrate pretreated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human ERG expressed in CHO cells by automated whole cell patch clamp Qpatch methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 204nMAssay Description:Inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 1 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 376nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/recombinant human full length p85alpha expressed in baculovirus infected ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of p110alpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate pretreated for 5 mins followed by NADPH addition and measured after 5 min...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His-tagged p85alpha/p110alpha E545K mutant expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 mi...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 m...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His-tagged p85alpha/p110alpha E542K mutant expressed in insect cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 186nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4EBP1 a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/recombinant human full length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate pretreated for 5 mins followed by NADPH addition and measured after 5 ...More data for this Ligand-Target Pair