BDBM50459233 CHEMBL4207543

SMILES OC(=O)c1noc(c1-c1cccc(c1)-c1cc(Cl)cc(Cl)c1)-c1ccccc1

InChI Key InChIKey=KFVNPLSZKCTJMO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50459233   

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB R136A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB H94A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB E129A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDual specificity protein phosphatase 3(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human VHR using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50459233(CHEMBL4207543)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of human PTP1B using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed