BDBM50459537 CHEMBL4217078

SMILES Cc1nn(c(C)c1NC(=O)C(OC(=O)Cc1c(C)[nH]c2ccccc12)C(F)(F)F)-c1ccccc1

InChI Key InChIKey=JBVBQGISBFEFTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459537   

TargetTrypsin(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459537(CHEMBL4217078)
Affinity DataIC50: 380nMAssay Description:Inhibition of trypsin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKallikrein-6(Human)
German Cancer Research Center (Dkfz)

Curated by ChEMBL
LigandPNGBDBM50459537(CHEMBL4217078)
Affinity DataIC50: 18nMAssay Description:Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed