BDBM50459690 CHEMBL2177146

SMILES COc1ccc(CC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)cc1OC

InChI Key InChIKey=TZRPLTHVBYHDBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459690   

TargetHeat shock protein HSP 90-alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459690(CHEMBL2177146)
Affinity DataIC50: 90nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human full-length C-terminal His-tagged HSP90alpha N-terminal domain (1 to 732 residues) expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459690(CHEMBL2177146)
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed