BDBM50459699 CHEMBL4215206::US12006283, Example 10

SMILES COc1ccc(cc1OC)C(C)C(=O)c1ccc(NCc2ccc(cc2)C#N)cc1OC

InChI Key InChIKey=RLPLABWTLRGNGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459699   

TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

US Patent
LigandPNGBDBM50459699(CHEMBL4215206 | US12006283, Example 10)
Affinity DataIC50: 600nMAssay Description:The experiment was performed in order to evaluate inhibitory activity against angiogenesis of the compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
US Patent

TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

US Patent
LigandPNGBDBM50459699(CHEMBL4215206 | US12006283, Example 10)
Affinity DataIC50: 600nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed