BDBM50460206 CHEMBL4228510

SMILES COc1ccc(C\C(=N/O)c2nc3ccc(OC)cc3o2)cc1

InChI Key InChIKey=WQJSDXPDBPDENI-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50460206   

TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460206(CHEMBL4228510)
Affinity DataIC50: 540nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460206(CHEMBL4228510)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460206(CHEMBL4228510)
Affinity DataKi:  2.89E+3nMAssay Description:Competitive inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate addition b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460206(CHEMBL4228510)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed