BDBM50460716 CHEMBL4227278

SMILES C=CC(=O)Nc1cccc(NC(=O)Nc2ccnc(Nc3ccc(cc3)N3CCOCC3)n2)c1

InChI Key InChIKey=LZKHGZOJRVSIFE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50460716   

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460716(CHEMBL4227278)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460716(CHEMBL4227278)
Affinity DataIC50: 644nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460716(CHEMBL4227278)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460716(CHEMBL4227278)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed