BDBM50461157 CHEMBL4227839

SMILES C[C@H]1N(Cc2c[nH]nc12)C1=NC(NCc2c(F)cccc2C(F)(F)F)c2cccc(C(N)=O)c2N1

InChI Key InChIKey=RLIXQSWDLDFNLY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461157   

TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Glaxosmithkline Research and Development

Curated by ChEMBL
LigandPNGBDBM50461157(CHEMBL4227839)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant human CD38 extracellular domain expressed in Pichia pastoris using NAD as substrate pretreated for 30 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline Research and Development

Curated by ChEMBL
LigandPNGBDBM50461157(CHEMBL4227839)
Affinity DataIC50: 158nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline Research and Development

Curated by ChEMBL
LigandPNGBDBM50461157(CHEMBL4227839)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed