BDBM50461379 CHEMBL4227156

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1cc(O[C@@H]2CCN(Cc3c(C)nn(C)c3C)C2)c2cnn(C)c2n1

InChI Key InChIKey=IUGGJYFHXIPYFI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50461379   

LigandPNGBDBM50461379(CHEMBL4227156)
Affinity DataIC50: 520nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50461379(CHEMBL4227156)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using PIP2 as substrate after 35 to 40 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50461379(CHEMBL4227156)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged PI3K p110delta/untagged recombinant full length human p85alpha expressed in baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50461379(CHEMBL4227156)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PI3Kdelta in Balb/c mouse splenocytes-derived B cells assessed as reduction in anti-IgM antibody-stimulated B cell proliferation after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed