BDBM50462093 CHEMBL4245250

SMILES CCCCn1c(nc(c1N(Cc1ccc2OCOc2c1)Cc1ccc2OCOc2c1)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=ZFXFSISPVAOURN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50462093   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human blood granulocytes assessed as inhibition of recombinant human C5a-induced CD11b expression on granulocytes pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human HL60 cells assessed as inhibition of recombinant human C5a-induced oxidative burst after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced intracellular calcium mobilization preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human C5aR1 expressed in Sf9 insect cell membranes co-expressing G-alphai2,G-beta1 and G-gamma2 assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced cell degranulation preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed