BDBM50462593 CHEMBL4246031

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1cc(OC[C@@H]2CCCN(Cc3cn(C)nc3C)C2)c2cnn(C)c2n1

InChI Key InChIKey=DSRSJMNLVHUVKX-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50462593   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50462593(CHEMBL4246031)Copy SMILESCopy InChI

Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/17/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Mouse)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50462593(CHEMBL4246031)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:Inhibition of PI3Kdelta in Balb/c mouse splenocytes-derived B cells assessed as reduction in anti-IgM antibody-stimulated B cell proliferation after ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/17/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL