BDBM50463566 CHEMBL4243299

SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(N)=O)c2[nH]c3ccccc3c12

InChI Key InChIKey=VETCDAPGXAEGJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50463566   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50463566(CHEMBL4243299)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50463566(CHEMBL4243299)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed