BDBM50463623 CHEMBL4239716

SMILES CSc1ccc(cc1)N(C)c1ncnc2occ(C)c12

InChI Key InChIKey=XGNXYCZBBNAIIL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50463623   

TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50463623(CHEMBL4239716)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of EGF-induced EGFR activation in human A431 cells pretreated for 60 mins followed by EGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50463623(CHEMBL4239716)
Affinity DataIC50: 14nMAssay Description:Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50463623(CHEMBL4239716)
Affinity DataIC50: 62nMAssay Description:Inhibition of PDGF-BB-induced PDGFRbeta activation in human SH-SY5Y cells pretreated for 60 mins followed by PDGF-BB addition and measured after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50463623(CHEMBL4239716)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of tubulin assembly in bovine brain homogenate assessed as reduction in turbidity increase preincubated for 15 mins followed by GTP additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed