BDBM50465361 CHEMBL4293005

SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)C1CC(F)(F)C1

InChI Key InChIKey=LBOXWECSMBRWQZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50465361   

TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465361(CHEMBL4293005)
Affinity DataEC50:  14nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed