BDBM50465647 CHEMBL4281278

SMILES CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1ccc(cc1)S(F)(=O)=O)C(=O)N1CCC[C@@H]1c1cncc(Cc2cccc(F)c2)n1

InChI Key InChIKey=OJNVAHCYXGMTQI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50465647   

TargetE3 ubiquitin-protein ligase XIAP(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50465647(CHEMBL4281278)
Affinity DataIC50: 17nMAssay Description:Displacement of AVPIAQKSEK-biotin from N-terminal His-tagged human recombinant XIAP BIR3 (253 to 347 residues) expressed in Escherichia coli BL21(DE3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50465647(CHEMBL4281278)
Affinity DataIC50: 20nMAssay Description:Displacement of AVPIAQKSEK-biotin from XIAP BIR3 Lys322A mutant (unknown origin) after 1 hr by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50465647(CHEMBL4281278)
Affinity DataIC50: 200nMAssay Description:Displacement of AVPIAQKSEK-biotin from cIAP1 BIR3 (unknown origin) after 1 hr by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 3(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50465647(CHEMBL4281278)
Affinity DataIC50: 353nMAssay Description:Displacement of AVPIAQKSEK-biotin from cIAP2 BIR3 (unknown origin) after 1 hr by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
University of California Riverside

Curated by ChEMBL
LigandPNGBDBM50465647(CHEMBL4281278)
Affinity DataIC50: 1.04E+3nMAssay Description:Displacement of AVPIAQKSEK-biotin from XIAP BIR3 Lys311E mutant (unknown origin) after 1 hr by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed